I have written in the past about tipping points in human history and a belief that the world may experience its third tipping point sometime this century. A recent article via Holden Karnofsky hypothesizes that we live in the most important century in human history. Both views are driven by an underlying belief that the century likely delivers humanity altering changes. In my view, the combination of rapid knowledge expansion, artificial intelligence, machines, biotechnology, genetic engineering, our connectivity, and a new computing paradigm, are likely to change what it means to be human. In the article, the author argues that the 21st century could see our civilization develop technologies that allow rapid expansion throughout our currently empty galaxy. He argues all sides of a debate that ranges from impossible, to skeptical, to humanity altering.